Differential expression of junctional adhesion molecules in systemic sclerosis (SSc) skin
نویسندگان
چکیده
منابع مشابه
Junctional adhesion molecules in angiogenesis.
The process of new blood vessel formation from pre-existing vessels is known as angiogenesis. This process is important, both during physiological processes such as development and during wound healing, as well as during pathological processes, such as cancer and arthritis. Understanding the molecular mechanism of the regulation of angiogenesis and the identification of the key players involved...
متن کاملHigh frequency skin ultrasonography in systemic sclerosis
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
متن کاملJunctional adhesion molecule-A is abnormally expressed in diffuse cutaneous systemic sclerosis skin and mediates myeloid cell adhesion.
OBJECTIVE To investigate the role of junctional adhesion molecule-A (JAM-A) in the pathogenesis of systemic sclerosis (SSc). METHODS Biopsy specimens from proximal and distal arm skin and serum were obtained from patients with SSc and normal volunteers. To determine the expression of JAM-A on SSc dermal fibroblasts and in SSc skin, cell surface ELISAs and immunohistology were performed. An EL...
متن کاملThe Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFb and IFNc Distinguishes SSc Phenotypes
Background: Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. Methodology and Principal Findings: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12) or diffuse cutaneous SSc (dcSSc, n = 24). A further arbitrary subdivision was made between early ...
متن کاملThe Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes
BACKGROUND Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL FINDINGS Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12) or diffuse cutaneous SSc (dcSSc, n = 24). A further arbitrary subdivision was made between early ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2011
ISSN: 0003-4967
DOI: 10.1136/ard.2010.149104.9